Treating COVID-19 in a patient with multiple myeloma

April 4, 2020 / Margaret / 2 Comments

Some readers have recently been asking me about curcumin and Covid-19. Is it good or bad to be taking it if you contract coronavirus? Can it reduce your risk of contracting Covid-19? (See my post on vitamina D, incidentally.) I don’t know.

If I had any answers, believe me, I’d be publishing them…immediately.

Well, it just so happens that this afternoon I read a very interesting Science Daily article that may shed some light on this matter. It discusses the case study of ONE myeloma patient, in Wuhan, who was given an immunosuppressant drug, a monoclonal antibody, called tocilizumab. Here’s the link: https://www.sciencedaily.com/releases/2020/04/200403124931.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fmultiple_myeloma+%28Multiple+Myeloma+News+–+ScienceDaily%29

Okay, now that you’ve read the SD article, you can read the rest of my post. 😉

The main use of tocilizumab is to treat rheumatoid arthritis. The interesting bit, as far as I’m concerned, though, is that tocilizumab blocks IL-6. Remember IL-6? I haven’t talked about IL-6 in a long time, but, simply put, it’s a really good friend of multiple myeloma. Aha…

And, by reducing the expression of IL-6, tocilizumab helps control the effects of what is known as a “cytokine storm” (read this April 1 New York Times article for a good explanation of what happens to Covid-19 patients when their immune systems go wacky and begin churning out too many cytokines, which can lead to vital organ failure: https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html).

Okay, now for this: curcumin inhibits IL-6 AND suppresses the cytokines involved in cytokine storms. Yes, it does both the things that tocilizumab does, without all the side effects, which actually don’t look that bad–from a runny nose to urinary tract infections (well, okay, I’d rather not get a UTI!).

Does that mean that curcumin would work against coronavirus or indeed help lower our risk of getting this blasted virus? As I wrote above, I have no idea, even though, as we know, among other things, curcumin has anti-viral and anti-inflammatory properties.

All I can say is that this bit of news today is promising. Sure, this is only ONE single case study, but I can tell you that, on March 19, tocilizumab started being administered to 330 coronavirus patients in a hospital in Naples (Italy). At the end of this month, fingers crossed, we may have some results. Right now, Italian newspapers report that the director of this study has expressed “cautious optimism.” I also saw that the FDA has approved Phase III trials for treating Covid patients with tocilizumab.

We just have to wait and see…

But, while we’re waiting, I’m going to keep taking curcumin (actually, I’d never thought about stopping…!!!)…

Music that brings people together

April 1, 2020 / Margaret / 1 Comment

Last night Stefano and I watched a lovely TV program called, in Italian, “Musica che unisce,” literally translated as Music that unites.

In addition to comedians, actors (Luca ZIngaretti, whom I adore), dancers (Roberto Bolle) athletes (Federica Pellegrini), and even regular folks like us, 25 well-known Italian musicians (Andrea Bocelli, see photo below, and the Three Tenors, e.g.) got together, from their homes, to thank and raise money for Italy’s Protezione Civile, similar to a Civil Defense, which has the goal of predicting, preventing and managing national disasters and catastrophes, both natural and human-made. Together with our doctors and medical workers, the Protezione Civile has been amazing, simply amazing, during this disastrous coronavirus outbreak in Italy.

Last night’s program was really inspiring. The musicians played and sang from their homes, as I mentioned above…No audiences, no clapping, no cheering. Only…music. Yes, very inspiring. I confess that I got a bit emotional here and there. There were also a few doctors who explained what Covid-19 is and how to protect ourselves from it. One of the nicest moments was when doctors and nurses played and sang songs, too…

Italy has shown the world HOW to react to the spread, to the invasion of this horrible virus. Italians were THE FIRST to clap (in thanks to doctors and nurses) and sing from their windows and balconies. A united country. Yes, true, a minority of ignorant fools have ignored the lockdown rules, and many will be paying the consequences of their actions, but the same thing is happening in several European countries right now.

In general, though, we have all stayed at home, staying safe…not just for ourselves but for everyone else.

I am so proud of Italy…What an amazing country!

Thanks to Jacqueline, I was able to post the program here. Yes, it’s in Italian, of course, but there’s a lot of music, too, and beautiful images of this beautiful country (oh silly me, getting emotional again), so I hope that even those who don’t understand Italian will be able to enjoy it.

https://www.youtube.com/watch?v=c2Quaw-jxBY

STAY AT HOME!!! STIAMO A CASA!!!

Italy reacting to Covid-19

March 17, 2020 / Margaret / 3 Comments

Italians have shown the world how to react to a quarantine and lockdown imposed by the spread of Covid-19. Singing, clapping, dancing, and playing instruments from their balconies and terraces. This has been happening all over Italy, a sort of country-wide flash mob. For days now. Spain has picked up the message and is doing the same. It’s a way to feel united and also to help those who are alone and finding it difficult to stay indoors.

I have watched a lot of videos showing these impromptu Italian flash mobs–you can find heaps of them on YouTube–but the one that brought tears to my eyes towards the end (you will see why) is this one, prepared by Sanità Informazione, a healthcare-based newspaper.

This is instead a rather slick video on the notes of Italy’s national anthem, but it shows one of the prettiest towns on the Amalfi Coast, Positano, and I posted it mainly for that reason, to show how beautiful Italy is…

The flash mobs are happening in my neighborhood here in Florence, too. The other day, e.g., at the appointed Flash Mob time, I was out on my terrace, joining my neighbors in applauding and cheering the amazing, tireless work that our healthcare workers have been doing since this Covid-19 crisis began.

Italy has responded with determination and unity and, as one foreign journalist wrote recently, “This is why so many people through many centuries fall in love with Italy.”

Indeed. I am certainly madly in love with this country, and there is absolutely no other place I’d rather be right now.

As the current slogan goes, “Andrà tutto bene,” or “Tutto andrà bene,” which means: “Everything is going to be okay.” Children have been painting these words and drawing rainbows on signs and sheets that now are displayed on balconies in every city and town in Italy. I got this photo from the Internet, btw.

It’s a sign of hope…

Margaret's Corner

Author: Margaret