Natural COX-2 and NF-kB Inhibitors

May 2007. I found heaps of very useful information in Dr. Roberto Benelli (an Italian urologist)’s books on prostate cancer and curcumin. To be honest, it’s hard to decide where to begin. Today’s chosen topic: natural COX-2 inhibitors. I have written a bit about this enzyme, COX-2, which is an independent signal of a poor outcome in MM (see my Ellagic Acid Part II post). For comparison purposes, I added a list of natural NF-kB inhibitors, too. I copied both lists from Dr. Benelli’s book titled L’Inibizione delle Vie di Segnale Cellulare: il “Curcumin,” published in 2006. (Co-author: Marco Gavazzi.)

Four compounds, curcumin, EGCG, quercetin and resveratrol, are on both lists, which is good to know. My most interesting new discovery: holy basil (Ocimum sanctum), is a COX-2 inhibitor. Needless to say, I am adding holy basil to my future research list. Here are the lists:

 Natural COX-2 inhibitors: holy basil, berberine , curcumin, EGCG, ginger, common hop, fish oil, oregano, quercetin, resveratrol, rosemary, Chinese skullcap, vitamins A, E.       

Natural NF-kB inhibitors: allicin, curcumin, EGCG, genistein, gingko biloba, melatonin, quercetin, resveratrol, silymarin, sulphoraphane, vitamins A, C, E.
I looked up the items I didn’t recognize on Wikipedia: berberine is a plant alkaloid present in herbs such as berberis (barberry) and goldenseal; Chinese skullcap is also know as Scutellaria baicalensis, which is on my list of substances to be studied because, guess what?, one of its components has anti-MM effects (antiproliferative and apoptotic effects) in vitro. Yippee. I will post that information soon. Let’s see, what else? Silymarin is extracted from milk thistle, and sulphorophane is a well-known anti-cancer compound found in cruciferous vegetables…broccoli, etc. Allicin, of course, is extracted from garlic, and genistein from soy.


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