Curcumin and cachexia

May 13 2009 post. Today, while doing research on something different, I came across an abstract (see: that may be of interest to some of you.


Cachexia is a syndrome that unfortunately affects about 50% of cancer patients and, in general, people with chronic diseases such as AIDS or COPD. Symptoms are: progressive weight loss, muscle atrophy, fatigue, anemia, weakness and loss of appetite. The body basically stops absorbing nutrients. No matter how much you eat. From the little I read just now, this condition cannot be easily reversed…


Well, things may soon change. According to this recent study, in fact, curcumin didn’t just prevent weight loss in mice with colon tumours but also—in higher doses— resulted in approximately 25 % (P < 0.05) weight gain as compared with the placebo-treated animals. Holy cats!


In other words, curcumin prevented AND was even able to reverse cachexia. Another feather in curcumin’s impressive (and, by now, very large!) cap…


  1. Not only Curcumin, but also quercetin, reservatrol, and EPA omega 3 oil. will stop cachexia, modern medicine is lagging behind because they will not accept that natural unpatented substances are usefull

  2. It’s not that they won’t accept it, it’s that natural compounds are not patentable. There’s no money in it, esp compared to pharmaceutical interventions. Modern medicine is about pushing modern medicine. If modern medicine happens to be curative, well that works out well for big pharma since they have the corner on a cure. Hence, the disinterest unless of course they can ‘tweak’ the natural compound enough to call it a ‘drug’ and patent it, of course.

  3. Have any of you had cachexia? I have it and have been looking for something that will stop it. How much of these supplements does one to take on a daily basis to fight this?


  4. I have it too. Did you ever get an answer to how much of those supplements are recommended on a daily basis?
    Do these things reverse it as well? Thanks!!


  5. Did any of you 2 get a reply? My son has cachexia and his muscles is starting to be affected. What dose is recommended?

  6. There was no mention of dosage for humans in the article. The study was carried out on mice (in vivo) and human skeletal cells (in vitro).
    However, if you go to page 973, you will find that the authors used C3 Complex suspended in olive oil. And on page 970 there is more interesting information (again, relative to mice).
    You can do a search of the full paper (link provided below) for “dose” and “human,” if you are pressed for time and don’t want to read the whole study.
    If I were in your shoes, I would try at least six grams of C3 Complex a day and see if there is any improvement. But please remember that I’m not a doctor, only a patient!
    The full study is available online, which is helpful. Go to the PubMed abstract page (the link provided in this post, that is) and click on “Journals Online. Full text” (upper right). Then, when you get to the British Journal of Nutrition page, click on “View PDF.”

  7. I,ve been goin to Baylor in Dallas, things got slowly worse so we decided to switch to a clinical trial starting Wednesday the 30th. I noticed my appetite was almost gone and muscle mass was departing as well. Today was the first time I have heard of cachexia. Thanks for the shared knowledge. Now I have some place to start. The Doctors were’t goint to share….shame

  8. My fiance has it and I’ve been reading and reading and now I am overwhelmed where to start. Any ideas?
    I’ve read about Hydrazine Sulfate that will stop cachexia. Has anyone used this?

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