New curcumin myeloma clinical trial

Well, well, well, how about this bit of news??? Yesterday I wrote a quick Happy Holidays post that I would have published here today (Stefano and I are leaving tomorrow for a three-week holiday in Ireland, with two of our best friends and their young daughter), but then this morning I saw the news about a new clinical trial titled “Curcumin as adjuvant therapy to improve remission in myeloma patients: A pilot randomized clinical trial,” which I just had to share with you. How could I not? Wowsie!

Here is the link to the free, easy-to-read article: 

Check out the Conclusion: “Curcumin has an efficacy in improving overall remission and decreasing NF-kB, VEGF, TNF-a, and IL-6 levels in myeloma patients.”

And so we have more proof…and this proof comes from actual myeloma patients, not from cells grown in a Petri dish. The evidence is piling up!

I wonder when (or if!) our myeloma luminaries and organisations are going to wake up to the fact that curcumin has a real potential to help us myeloma folks at every stage of this cancer. If I could, I would tell them (the above luminaries and organisations) to ignore the profits and benefits (international conferences held in exotic locations, e.g.) they receive from the big pharmaceutical companies and to focus instead on us, their patients, and on our wellbeing. (Hah! Utopia, I know. Not going to happen…)

It’s so frustrating to see no move in that direction. And so we must move on our own, for example by printing out these articles and giving them to our specialists. It’s going to be a slow process, that’s for sure…But I see no other way at present.

We are the only ones who can push for a change…

Well, I’m about to go on a lovely holiday with some of my favorite people in the world, so, to be honest, right now I want to think positive, happy thoughts and not go on a long rant about big Pharma and the obvious (financial) hold it has over the cancer system. So…enough.

And now I have some packing to do, including putting my bottle of curcumin inside my carryon suitcase. Can’t forget my curcumin! 🙂

I hope you all have a lovely August and stay well (wear your masks!). I’ll see you after I get back, at the end of the month…I’m going to try to get some nice shots of the beautiful Irish coastline for the blog. Fingers crossed. Anyway, take care, everyone, and…ciao🙂

MD Anderson Curcumin Myeloma Clinical Trial Results: Preliminary Comments

First, a blog notice: yesterday I sort of updated my "Curcumin in the News" and "Italian Curcumin References" links. My New Year’s Resolution number 2861 (!) is to keep these links a bit more updated, and the same goes for some of my more sadly neglected blog pages, such as the recipe one.

I was waiting to read the full MD Anderson report before discussing the curcumin-myeloma trial results here, but Chris’ comment on yesterday’s post, on top of all the private messages I have received to this regard, made me decide this morning to go ahead and write a post even though, I repeat, I don’t have ALL the facts and numbers. I will certainly have more to say on the topic as soon as I read the full study, which hasn’t been published yet. In the meantime, for what it’s worth, here goes!

Oh, before proceeding, though, I wanted to mention that you can view Prof. Aggarwal’s ASH presentation on the International Myeloma Foundation’s website: One important thing he points out is that, even when as little as TWO grams of curcumin were administered to some of the myeloma patients in the clinical trial, after four weeks a downregulation of the evil (I added the "evil" part) transcription factor NF-kappaB was observed. After 24 weeks, no NF-kappaB could be detected in some of these patients. Not even a glimpse. And they were taking only two grams. How about that?

Prof. Aggarwal also says that cancer treatment requires the inhibition of more than a single pathway, which makes curcumin an ideal agent since it inhibits several different pathways involved in cancer progression. A key sentence: “Although this study was very interesting and we did find the downregulation of various markers for cancer in MM pts, no objective responses were noted. So, in the future, I think that it would be interesting to combine curcumin with some of the existing treatments.”

A few introductory comments of my own: we know from the huge number of studies published on curcumin that this biologically active compound has extraordinary anticancer properties in vitro. Frequently, however, extraordinary properties do not work as well, or indeed at all!, when applied in vivo. It’s one thing to inject curcumin directly into some cancerous cell cultures, quite another for us to swallow a capsule or pill and hope that eventually our myeloma cells will be blasted by enough active curcumin. As we know, when taken orally, most of the swallowed curcumin gets transformed into (probably) less powerful, perhaps even useless metabolites (first-pass metabolism etc.). The issue of bioavailability pops up, again.

So the big question is: how do we get enough still-active curcumin delivered right smack into our cancerous cells? Eh. Still working on that!

ASH abstract. Thanks to the kindness of someone who sent me the abstract presented by the MD Anderson curcumin myeloma trial researchers at the American Society of Hematology (ASH) meeting held in December 2007, I was able to read some of the preliminary clinical trial data. Jan 15 UPDATE: here is the link to the abstract:

The abstract tells us that the MD Anderson clinical trial (which is still recruiting patients, by the way) consisted of 29 myeloma patients with asymptomatic, relapsed/refractory, or plateau phase disease. They took curcumin capsules without bioperine, 2, 4, 6, 8, or 12 grams/day in two divided doses, OR curcumin capsules with bioperine, 10 grams, again twice a day. The abstract tells us that “At least 6 pts are enrolled at each dose level; 3 on the curcumin arm and 3 on the curcumin + bioperine arm.” Conclusions: “Of the 29 evaluable pts treated so far, no objective responses have been seen. Twelve pts continued treatment for more than 12 weeks and 5 (1 patient at 4 grams, 2 pts at 6 grams, and 2 pts at 8 grams dose levels) completed one year of treatment with stable disease.”

Key words: “stable disease.” These patients remained STABLE. My glass is half full, not half empty. Always. 

Most of the people with whom I have corresponded privately have focused on the “disappointing” trial results, that is, not one of these myeloma patients experienced a decrease in her/his myeloma markers. But that is precisely what I expected since my own results from my capsule experiments have been similar. So I am not disappointed. Not at all. Sure, it would have been great to see a decrease at least in one patient since I (myself) did experience a fluky IgG decrease in September of 2006 that may or may not be ascribed to my curcumin capsules with bioperine intake (update: my parents pointed out to me that the way I worded this last sentence makes it seem as though my September 2006 IgG decrease has been my ONLY decrease to date. That is not the case, of course. I have experienced decreases  while taking curcumin powder. So I thought I should clarify that I was referring to capsules here). I say "fluky" because at the time, pre-blog era, I wasn’t keeping good records on my intake, and when, months later, I repeated the capsule with bioperine experiment my results were stable, that is, there was no decrease. Hmmm.

Well, anyway, in my view, the following trial results are even more important than disease stability (which is important enough!): “Oral administration of curcumin significantly downregulated the constitutive activation of NF-kB (at 3 months a median reduction of 77%, p<0.0001) and STAT3 (69%, p<0.001), and suppressed COX2 (66%, p<0.0001) expression in most of the pts at each of the monthly time points.”

Check out those percentages! Accipicchia! Excellent! This means that curcumin is able to inhibit all the overly active transcription factors that make myeloma cells proliferate…and this happened IN VIVO! That is, in spite of its low oral bioavailability, curcumin was still able to inhibit these bothersome pathways in myeloma patients. In vitro translates to in vivo. That result is not at all disappointing but very very exciting. To me, at least. Oh, I can’t wait to read the full report.

Curcumin won’t cure myeloma (or perhaps it could, but it would have to be injected directly into each cell, I am afraid…), but if it can keep me and others, I hope!, stable or even decrease my/our counts until someone finds a way to exterminate the cancerous STEM cells (DMAPT trial, where art thou?), well, that’s fine by me. As Earl (Beth’s blog reader, see yesterday’s post) wisely declares, “always believe you can do it…if you think you can, you can…if you think you can’t, you can’t.”

I think I can.