Guggulsterone also inhibits osteoclastogenesis in multiple myeloma and breast cancer cells…

Yesterday I forgot to give proper mention to a 2006 “Clinical Cancer Research” study showing that guggulsterone also inhibits osteoclastogenesis, which is, in very simple terms, the process of bone destruction that has such terrible consequences in multiple myeloma…So the fact that guggulsterone inhibits this process could be super important…

I wrote about this study in my June 8 2007 post, but now that I’m actually taking this supplement, I thought I would re-read it: And it reminded me that Ayurvedic medicine has used guggulsterone (well, the gum resin, rather) to treat bone fractures and osteoarthritis. So my hope right now is that the fabulous guggul extract has a preventive effect on bone resorption.

That would be very nice indeed! 


  1. I reviewed the Clinical Cancer Research article, Guggulsterone Inhibits Osteoclastogenesis. I was unable to ascertain the specific dosage or commerical manufacturer that one would consider when planning to take this supplement. Perhaps I missed something. Please advise.

  2. Margaret

    Not only would I be interested in your dosage of guggal but I am more interested in what brand you bought.

  3. I’m taking Gugulipid (Natrol is the brand), which I bought from Vitacost (but you might check around for a better price). I began by following the directions: two caps per day/with meals, but I’ve moved up to three caps now. That adds up to 1500 mg, which is halfway between the low and high dose (same stuff) used in a 2003 cholesterol study. I wouldn’t go above that.

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