A longtime myeloma list friend/blog reader, thanks!, sent me the link to a new “Blood” study (http://tinyurl.com/lkmrz5) on an antifungal substance called ciclopirox olamine, or CPX, which has been found to decrease cell growth and viability of malignant leukemia, myeloma, and solid tumor cell lines as well as primary AML patient samples at low micromolar concentrations that appear pharmacologically achievable. Furthermore, oral CPX decreased tumor weight and volume in 3 mouse models of leukemia by up to 65% compared to control without evidence of weight loss or gross organ toxicity. (hmmm, I am not entirely sure that I like the sound of “gross organ toxicity”…)
But get this: oral CPX has the ability to target leukemia stem cells. It targets STEM cells. Yes, the bloody evil STEM CELLS! I had to read that part at least twice before it sank in. Well…well…and…WELL!
I don’t know much about this substance, except what I read in the abstract (for instance that it is also an iron chelator)…but a quick bit of online poking led me to a couple of interesting studies, such as http://tinyurl.com/mxn3be. Unfortunately, I had to stop doing more research on this topic and, in fact, don’t have the time right now (=I have a complicated legal translation to do, sigh and double-sigh!) to connect the dots that I feel are lying just beyond my reach…(of course, I could be entirely wrong about the existence of any dots…aaah, if only I had more time…)
Well, as soon as possible, I will ask Sherlock if she would kindly get me the full study…in the meantime, based on what the study abstract tells us, CPX sounds like a very promising substance, to say the least…! I mean, holy cats, let’s say that you have toenail fungus AND myeloma…well, with CPX you might be able to treat both conditions…what an amazing thought…!
And now, before diving back into the peculiar and rather maddening world of Italian-English legalese, I would like to wish my Mom a very HAPPY BIRTHDAY! Auguri, mamma, ti voglio tanto beneee! Un bacione!