Omega-3 study on ES-CLL, MGUS and SMM patients

A blog reader (thanks!) sent me the link (see below) to this Phase II study listed on the Clinical Trials website. The main purpose of the study is to determine if the Omega 3 supplementation will help prevent or delay progression of the disease to a stage that requires treatment. Well, that sounds good to me, especially since my regular regimen includes 4 grams of fish oil/day, which is slightly more than what these patients take in the first month before building to higher doses (the highest dose will be 11 grams and 250 mg/day).

The study is still recruiting, by the way. For more information, see: http://tinyurl.com/n9r49u

5 Comments

  1. I’ve been taking 4 grams of distilled fish oil daily for quite some time now. So far so good. My paraproteins are only trace, showing up on immunofixation, but too low to show up on electrophoresis now. Used to be they showed up on both. At about the same time, I also started taking alpha lipoic acid for neuropathy and autoimmune liver inflammation. Something’s working! The toes seem better, too.

  2. P.S. Unlike the omega 3’s in flax seed oil, the ones in fish oil do not have to be converted in order to become usable. Only a small fraction of the omega 3’s in flax seed oil become converted to usable form.

  3. Flaxseed oil contains alpha linolenic acid(ALA) and this doesn’t have to be converted to EPA or DHA, that are present in fish oil, to work.
    http://www.ncbi.nlm.nih.gov/pubmed/9150374

    “Both alpha-linolenic (ALA) and eicosapentaenoic acids (EPA) were toxic to SP 2/0 mouse myeloma cells in vitro. On the other hand, linoleic acid (LA), gamma-linolenic acid (GLA), di-homo-gamma linolenic acid (DGLA), arachidonic acid (AA), docosahexaenoic acid (DHA) and oleic acid (OA) were much less effective in their growth suppressive actions.”

    Also see this study for the effects of flaxseeds and flaxseed oil against established mammary tumors.
    http://www.ncbi.nlm.nih.gov/pubmed/8681458

    And here is a study comparing linseed/flaxseed oil with fish oil against mammary tumor growth. Although I have no idea what would work better against something as multiple myeloma.
    http://www.ncbi.nlm.nih.gov/pubmed/1979807

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