“Long-term follow-up of curcumin treated MGUS/SMM patients – an updated single centre experience”

In an email I received yesterday, Dr. Terry Golombick notified me that her team’s most recent article has been  published in the Journal of Hematology and Medical Oncology. It is available for free online…just click here: goo.gl/cEP93h

keep calm and turmeric onAhhhh. Wonderful…absolutely wonderful.

Wonderful, because finally…FINALLY (!!!)…we have a long-term look at a GROUP of MGUS and SMM patients taking curcumin. These are those who participated in the Australian MGUS/SMM study and who “continued to take curcumin over a number of years, of their own volition, even though the studies in which they were participating are complete.”

So this is a “long-term follow-up of 13 MGUS/SMM patients who have been taking curcumin (at a dose of 4 -8 grams daily) for a period of 3-9 years.”

Only one patient, who had cardiac amyloidosis (!), went on to full-blown myeloma and is currently undergoing conventional treatments. The rest of the patients are doing quite well, some better than others…anyway, you can read all the details in the report…

I really hope that this report will encourage more and more centers to start giving curcumin to their MGUS and SMM patients and, why not?, to their MM patients as well. At this point, I could go into a tirade about the short-sightedness of conventional medicine, but, at least for now, I’d rather look at the positive side, which is the publication of some CASE STUDIES, like the one concerning my blog reader D., and this Australian one.

I would like to end this post by stating that we all owe a large debt of gratitude to dedicated researchers like Dr. Golombick who have overcome all sorts of obstacles (I’m sure of that!!!) to help patients like us have the best quality of life possible, for as long as possible…

To all the Golombicks of the world: thank you, thank YOU, THANK YOU!!!  🙂 keep calm and watch and wait

By the way, let me remind you that Dr. Golombick and her team have set up a useful website for all of us who have a type of blood cancer. I’ve talked about it here on the blog, but just in case you missed that post, here is the link: https://www.watchandwaitbloodcancers.com/

KEEP CALM AND…

WATCH AND WAIT!!!!!! 

IL-1beta involved in progression from inactive to active myeloma

I found out about this wonderful little gem from a couple of myeloma list friends (thank you both so very much, D & D!). It’s an editorial (see: http://tinyurl.com/b7z59z) on a Mayo Clinic study titled “Targeting the Pathogenic Role of Interleukin 1beta in the Progression of Smoldering/Indolent Myeloma to Active Disease,” (abstract: http://tinyurl.com/acqlkb; full study: http://tinyurl.com/akqd4r). I haven’t read the full study yet (I will read it tomorrow…it requires more attention and care than I can give it at the moment: ). Both can be found in the February 2009 Mayo Clinic Proceedings. At any rate, I am basing my post on the editorial (shorter and easier to read than the full study…).

 

47 patients, all at the inactive or smouldering myeloma stage (=my stage) but at high risk of progression, participated in the Mayo study, which was carried out between 2002 and 2007. The idea was to answer the fundamental question: WHAT THE HECK makes folks progress from inactive to active myeloma?

 

Apparently what happens is that IL-1beta, another of those beastly pro-inflammatory and pro-angiogenic cytokines, induces marrow stromal cells to produce large amounts of interleukin 6 (IL-6), thereby promoting the survival and expansion of the myeloma cells

 

The researchers confirmed their theory that reducing the activity of IL-1beta does, in fact, significantly increase progression-free survival (PFS) in these high-risk patients. This is extraordinary!

 

And now read this: blocking IL-1beta reduces IL-6 as well as the proangiogenic chemokine IL-8, therefore the use of IL-1beta-blocking strategies may result in new standards of therapy for high-risk patients with SMM/IMM. WOWIE!!!

 

In the study, all the smouldering myeloma patients were given anakinra, an IL-1beta inhibitor that is used for the treatment of rheumatoid arthritis and autoinflammatory diseases. I should add that 25 patients were also given a low dose of dexamethasone. Two of the them remained stable for about four years, and in fact, at the time of this writing, progression to active disease has not yet occurred […]. Since, as I mentioned, I haven’t yet read the actual study, I don’t know what happened in the other 23 cases…

 

Another significant excerpt from the editorial: In the study, patients with a decrease in CRP levels were more likely to have stable disease, confirming that effectively blocking IL-1beta (using CRP levels as the marker for IL-1beta activity) can halt progression to active myeloma.

 

Halt progression to active myeloma…aaaaah, how sweet those five little words sound…

 

Hmmm, but WHY am I so excited that I could skip and dance all around my study (probably will, as soon as I post this)?

 

Because, drum roll!, CURCUMIN INHIBITS IL-1BETA!!! (See, e.g.: http://tinyurl.com/b7yr3j and http://tinyurl.com/bgqud4) There are heaps of studies on this topic, in fact, probably much much better than the above two that I found after a lightning search…but right now I am too elated and, well, in a bit of a hurry–it’s almost dinnertime–to see if I can find the perfect one…I just want to go ahead and post this bit of good news!

 

More good news: curcumin is not the only one. Here is a list of the other natural IL-1beta inhibitors that I have found thus far (ah, but my quest has only just begun, so there will probably be more…):

 

1.     quercetin (strongly) http://tinyurl.com/dfy39r and http://tinyurl.com/c6v3np

2.     omega-3 http://tinyurl.com/c2ksmg

3.     genistein http://tinyurl.com/cbtpsr

4.     EGCG http://tinyurl.com/andmdj

5.     resveratrol http://tinyurl.com/cmnayw

6.     ellagic acid (on my to-be-tested list) http://tinyurl.com/bgvutf

 

I will stop here because I want to go give my husband a big bear hug…and do another little jig of joy around the room on the way! Yippity yippity doodle! Evvaiiiii, grandeeeee!!! 🙂