When I first read this bit of news, I thought it was a joke: http://goo.gl/E1ufJA
But no, not at all. On the contrary, it makes perfect sense: by bypassing the stomach, the chewing gum system should be able to deliver more curcumin to cancer cells via the oral mucosa.
The oral mucosa is basically the skin inside the mouth, which has a rich blood supply and is quite permeable. Without going into too many details (such as first-pass metabolism in the liver and pre-systemic elimination in the gastrointestinal tract…), what happens is that substances absorbed inside the mouth enter the blood system immediately, without passing through the gastrointestinal tract where absorption is slow and subject to attacks by potentially degrading enzymes.
In a nutshell: the oral mucosa delivery system should be great for substances that are poorly absorbed in the gastrointestinal tract, such as curcumin.
That is precisely why I used to prepare a C3 Complex curcumin powder concoction using melted dark chocolate and honey. I would keep small blobs of this concoction inside my mouth for as long as possible, under my tongue (in an attempt to maximize absorption). I still add C3 Complex curcumin to our food whenever possible, and this fall I plan to experiment with coconut oil, too.
Well, how about curcumin chocolates…curcumin lollipops…curcumin candy canes? Hey, the sky’s the limit! 🙂
And, by the way, all my very best wishes to Dr. Nathan and her work! Hip hip hooray!