I was looking up the medicinal properties of honey and came across a fascinating bit of news by pure coincidence. In 2006, an Iranian pharmacist administered bee venom therapy (BVT) to a patient with MM. The patient improved considerably but, as soon as the venom therapy was stopped, his markers worsened (http://tinyurl.com/3dyj3l). I have not been able to get my hands on the particular study, so if anybody has access to the March 2006 issue of the Journal of the American Apitherapy Society, please let me know! Bee venom is no joke, as I quickly discovered. It stimulates the body to release cortisol, a natural steroid, and is being used to treat multiple sclerosis and rheumatoid arthritis.
Researchers at CSIRO Molecular Science in Western Australia have been trying to modify bee venom to develop cancer treatments that would target only cancer cells, not healthy ones, and cause very few side effects. See: http://tinyurl.com/ywgmlx The main active ingredient in bee venom is melittin, a molecule with potent anti-inflammatory properties (according to Wikipedia, it appears to be 100 times stronger than hydrocortisone!) that attaches to the membranes of cells, causing them to collapse and die. The researchers’ task is to modify this molecule in order to prevent allergic/toxic reactions while maintaining intact its cancer-killing potential. The idea is to create an immunotoxin, that is, a combination of melittin and a specific cancer-killing antibody: melittin-MABs (or melittin monoclonal antibodies). If these attempts are successful, this might mean no more chemotherapy with hair loss, vomiting, weight loss, etc. Just think: only cancer cells would die.
A bit more research led me to the following study (http://tinyurl.com/yvgh3o) published in the International Journal of Oncology in 2003: a melittin/avidin conjugate was successfully used to reduce tumours both in vitro and in vivo. Avidin is a glycoprotein, by the way, and was coupled with melittin to reduce its toxicity. At any rate, this conjugate ignored healthy cells but targeted MMP-2 (matrix metalloproteinase 2), an endopeptidase that plays an important role in cancer metastasis and is active in MM, too. See, for instance, http://tinyurl.com/27m7wm, http://tinyurl.com/3exzcd and http://tinyurl.com/2uxeom
Bee venom, a possible cancer treatment? Who would have ever thought?!