<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	>
<channel>
	<title>Comments for Margaret's Corner</title>
	<atom:link href="http://margaret.healthblogs.org/comments/feed/" rel="self" type="application/rss+xml" />
	<link>http://margaret.healthblogs.org</link>
	<description>Life with Myeloma</description>
	<pubDate>Fri, 25 Jul 2008 01:16:05 +0000</pubDate>
	<generator>http://wordpress.org/?v=2.5.1</generator>
		<item>
		<title>Comment on Blood tests, more on cyclopamine and&#8230;Cancer Vixen by Massoud Garrossian</title>
		<link>http://margaret.healthblogs.org/2008/02/26/blood-tests-more-on-cyclopamine-andcancer-vixen/#comment-4696</link>
		<dc:creator>Massoud Garrossian</dc:creator>
		<pubDate>Thu, 24 Jul 2008 02:58:10 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/2008/02/26/blood-tests-more-on-cyclopamine-andcancer-vixen/#comment-4696</guid>
		<description>Dear Margaret.
 As you may know Logan Natural Products Is producing Cyclopamine- Tartarate.Second patient just finished his first use of this compound, He send a massage that he feel good , with no side effect, It take one months to measure his MM Point 
 Best Regards
  Massoud</description>
		<content:encoded><![CDATA[<p>Dear Margaret.<br />
 As you may know Logan Natural Products Is producing Cyclopamine- Tartarate.Second patient just finished his first use of this compound, He send a massage that he feel good , with no side effect, It take one months to measure his MM Point<br />
 Best Regards<br />
  Massoud</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Brain food by Rudi</title>
		<link>http://margaret.healthblogs.org/2008/07/21/brain-food/#comment-4670</link>
		<dc:creator>Rudi</dc:creator>
		<pubDate>Tue, 22 Jul 2008 16:49:25 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=864#comment-4670</guid>
		<description>Hi Margaret,

this YouTube video shows the procedure to prepare my breakfast.

http://de.youtube.com/watch?v=RSoddptWL0s</description>
		<content:encoded><![CDATA[<p>Hi Margaret,</p>
<p>this YouTube video shows the procedure to prepare my breakfast.</p>
<p><a href="http://de.youtube.com/watch?v=RSoddptWL0s" rel="nofollow">http://de.youtube.com/watch?v=RSoddptWL0s</a></p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Brain food by Rudi</title>
		<link>http://margaret.healthblogs.org/2008/07/21/brain-food/#comment-4668</link>
		<dc:creator>Rudi</dc:creator>
		<pubDate>Tue, 22 Jul 2008 16:08:05 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=864#comment-4668</guid>
		<description>Hi Margaret,
i take flaxseed oil since two years. 

Look here:
http://www.westonaprice.org/knowyourfats/flaxseed.html

Ciao
Rudi</description>
		<content:encoded><![CDATA[<p>Hi Margaret,<br />
i take flaxseed oil since two years. </p>
<p>Look here:<br />
<a href="http://www.westonaprice.org/knowyourfats/flaxseed.html" rel="nofollow">http://www.westonaprice.org/knowyourfats/flaxseed.html</a></p>
<p>Ciao<br />
Rudi</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Brain food by minnesotadon</title>
		<link>http://margaret.healthblogs.org/2008/07/21/brain-food/#comment-4667</link>
		<dc:creator>minnesotadon</dc:creator>
		<pubDate>Tue, 22 Jul 2008 15:37:44 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=864#comment-4667</guid>
		<description>I believe in LDN too - especially combined with curcumin, EGCG, quercetin, resveratrol, and a few others.  I think that my myeloma was stable for a few months on that combo, though the bone lesions were already active so something more had to be done.

Fish is good.  Nuts are good.  We've recently started having sardines from time to time, in addition to salmon and some other fish.  

Think I'll go have a few cashews ...</description>
		<content:encoded><![CDATA[<p>I believe in LDN too - especially combined with curcumin, EGCG, quercetin, resveratrol, and a few others.  I think that my myeloma was stable for a few months on that combo, though the bone lesions were already active so something more had to be done.</p>
<p>Fish is good.  Nuts are good.  We&#8217;ve recently started having sardines from time to time, in addition to salmon and some other fish.  </p>
<p>Think I&#8217;ll go have a few cashews &#8230;</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Double-edged sword by minnesotadon</title>
		<link>http://margaret.healthblogs.org/2008/07/19/double-edged-sword/#comment-4666</link>
		<dc:creator>minnesotadon</dc:creator>
		<pubDate>Tue, 22 Jul 2008 15:13:24 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=861#comment-4666</guid>
		<description>Hmmm - the double-edged sword.  Too much iron defeats the benefit of curcumin, but too little means depressed hemoglobin.  Yikes.  

Maybe I'll just settle for whatever iron comes along in the food, as I have been doing.</description>
		<content:encoded><![CDATA[<p>Hmmm - the double-edged sword.  Too much iron defeats the benefit of curcumin, but too little means depressed hemoglobin.  Yikes.  </p>
<p>Maybe I&#8217;ll just settle for whatever iron comes along in the food, as I have been doing.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Brain food by Linda Giovanna Zambanini, RN, MIS</title>
		<link>http://margaret.healthblogs.org/2008/07/21/brain-food/#comment-4656</link>
		<dc:creator>Linda Giovanna Zambanini, RN, MIS</dc:creator>
		<pubDate>Mon, 21 Jul 2008 17:32:09 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=864#comment-4656</guid>
		<description>Hi Margaret,

I have written to you before but can't find your email address. Unfortunately i can't figure out how to post a new thread on your blog so i am posting in response to your first post here. 

I think i wrote to you before about Low Dose Naltrexone? It has been used for many cancers including multiple myeloma. Today when doing some more research on LDN i came upon this link by a woman who successfully used LDN to treat her father who had MM: http://susiemaui.com/low_dose_naltrexone.htm


I am a big fan of LDN - i take it for my fibromyalgia with nothing short of miraculous results. It's an immunomodulator and  is used for a wide range of disorders affected by the immune system from MS, to autoimmune disease (RA, SLE, Crohn's disease), to HIV, and numerous cancers including MM.  I hope you will do some research into this as i think you will find it worthwhile. 

Once again your site is an absolute joy to read! The best novel adjuvant cancer site on the net in my opinion!!!

 Di nuovo - mi stupisce che tu non sia una biologista ma solamente una professoressa d'italiana ed inglese! :) 

Thanks for your wonderful site! 

Ciao
Linda</description>
		<content:encoded><![CDATA[<p>Hi Margaret,</p>
<p>I have written to you before but can&#8217;t find your email address. Unfortunately i can&#8217;t figure out how to post a new thread on your blog so i am posting in response to your first post here. </p>
<p>I think i wrote to you before about Low Dose Naltrexone? It has been used for many cancers including multiple myeloma. Today when doing some more research on LDN i came upon this link by a woman who successfully used LDN to treat her father who had MM: <a href="http://susiemaui.com/low_dose_naltrexone.htm" rel="nofollow">http://susiemaui.com/low_dose_naltrexone.htm</a></p>
<p>I am a big fan of LDN - i take it for my fibromyalgia with nothing short of miraculous results. It&#8217;s an immunomodulator and  is used for a wide range of disorders affected by the immune system from MS, to autoimmune disease (RA, SLE, Crohn&#8217;s disease), to HIV, and numerous cancers including MM.  I hope you will do some research into this as i think you will find it worthwhile. </p>
<p>Once again your site is an absolute joy to read! The best novel adjuvant cancer site on the net in my opinion!!!</p>
<p> Di nuovo - mi stupisce che tu non sia una biologista ma solamente una professoressa d&#8217;italiana ed inglese! <img src='http://margaret.healthblogs.org/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' /> </p>
<p>Thanks for your wonderful site! </p>
<p>Ciao<br />
Linda</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Message from my students by pat miner</title>
		<link>http://margaret.healthblogs.org/2008/07/18/message-from-my-students/#comment-4651</link>
		<dc:creator>pat miner</dc:creator>
		<pubDate>Mon, 21 Jul 2008 03:42:34 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=859#comment-4651</guid>
		<description>thank you all or as we say here in mississippi y'all! for your input re. dr. ray powles.
 the article that paul gave the link to was great! 

we will still welcome further comments
many thanks 
pat</description>
		<content:encoded><![CDATA[<p>thank you all or as we say here in mississippi y&#8217;all! for your input re. dr. ray powles.<br />
 the article that paul gave the link to was great! </p>
<p>we will still welcome further comments<br />
many thanks<br />
pat</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Mayo EGCG study by nicki</title>
		<link>http://margaret.healthblogs.org/2008/03/10/mayo-egcg-study/#comment-4649</link>
		<dc:creator>nicki</dc:creator>
		<pubDate>Mon, 21 Jul 2008 02:08:24 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/2008/03/10/mayo-egcg-study/#comment-4649</guid>
		<description>Hi...I would hold off on the honey. Honey acts just like sugar in the body. Sugar feeds cancer cells.</description>
		<content:encoded><![CDATA[<p>Hi&#8230;I would hold off on the honey. Honey acts just like sugar in the body. Sugar feeds cancer cells.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Mayo EGCG study by beth</title>
		<link>http://margaret.healthblogs.org/2008/03/10/mayo-egcg-study/#comment-4639</link>
		<dc:creator>beth</dc:creator>
		<pubDate>Sun, 20 Jul 2008 18:29:52 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/2008/03/10/mayo-egcg-study/#comment-4639</guid>
		<description>Hi Margaret and Sherlock and kitty,

I am now 63, and was diagnosed with cll in 2007, Rai stage 2, at Mayo, among other places including dr.Rai.  I had read about the green tea, EGCG study before going to Mayo and of course asked about it.  at the time,  2007 the second phase, I believe,  was on hold, but due to resume.  I signed up, agreeing to stop using ANY green tea at all for at least six months.  I did, and still the study did not commence.   I sought the help of Dr. Raymond Chang in NY, Meridian Medical. org whom I had consulted several times before,  (hematology and immunolgy).   He found the type/strength they use at Mayo and got it for me.   I began taking it.   I can't of course get anyone to correlate any of my blood work to what I have been doing.  (2, 500 mg caps of this highly concetrated imported EGCG  2 x a day, equal to a zillion cups of green tea)
I am stable, with symptoms, sweats, weight loss, fatigue etc.  I also have chronic Squamous Cell Carcinoma, 5 surgeries on one ear over four years, and the two don't do well together)    I have however seen a drop in my awc.  from the 14 - 12   to 10, just above the normal.  no  one comments however,, medical politics, not their study, not in study, no 'controls' I get it... but it's frustrating none the less.   I will of course continue to use the EGCG, and drink my usual 6 - 8  8 0z glasses of green tea with raw honey every day, almost my only beverage... love it.   

Dr. Chang also found a study that uses theophyllin for cll,  I tried the pill form and it was too strong for me, but now use an old standby, elixophyllin, a liquid, used for ever as broncho dialator,  CLL seems to cause thick mucous in some patients, I'm one,  after three pneumonias and almost not able to breathe,  that worked wonders, along with singulair, which I researched and switched to after I tore a shoulder using quinolones (antibiotics) and advair and nasocort, both contain steriods, . seems singulaire has also been used in some cancers.  it's main ingred seems to target leukotriens, also a player in cll.
good source for CLL patients...www.clltopics.org   Chaya is amazing and goes into a lot on alternative, plus trad ... explains so one can understand.  (searchable by substance, disease, trial etc)

cox 2 inhibitors too, but usually perscrip which I can't take, GERD...
looking at Zyflamend for that.  might also help some of the inflamatory pains ... just have to find the time to check the individ ingreds agianst all of my other drugs and add ons. 

my bottom line is if something is not toxic, and might help, and reduces symptoms, I'm on line.   so thanks,  

ps, have had no trad chemo etc,  only IVig infusions once a month due to immunoglobulinemia and repeated pneumonias.  seems to help too.  

wonderful cat you have there.    take care and thanks,   beth</description>
		<content:encoded><![CDATA[<p>Hi Margaret and Sherlock and kitty,</p>
<p>I am now 63, and was diagnosed with cll in 2007, Rai stage 2, at Mayo, among other places including dr.Rai.  I had read about the green tea, EGCG study before going to Mayo and of course asked about it.  at the time,  2007 the second phase, I believe,  was on hold, but due to resume.  I signed up, agreeing to stop using ANY green tea at all for at least six months.  I did, and still the study did not commence.   I sought the help of Dr. Raymond Chang in NY, Meridian Medical. org whom I had consulted several times before,  (hematology and immunolgy).   He found the type/strength they use at Mayo and got it for me.   I began taking it.   I can&#8217;t of course get anyone to correlate any of my blood work to what I have been doing.  (2, 500 mg caps of this highly concetrated imported EGCG  2 x a day, equal to a zillion cups of green tea)<br />
I am stable, with symptoms, sweats, weight loss, fatigue etc.  I also have chronic Squamous Cell Carcinoma, 5 surgeries on one ear over four years, and the two don&#8217;t do well together)    I have however seen a drop in my awc.  from the 14 - 12   to 10, just above the normal.  no  one comments however,, medical politics, not their study, not in study, no &#8216;controls&#8217; I get it&#8230; but it&#8217;s frustrating none the less.   I will of course continue to use the EGCG, and drink my usual 6 - 8  8 0z glasses of green tea with raw honey every day, almost my only beverage&#8230; love it.   </p>
<p>Dr. Chang also found a study that uses theophyllin for cll,  I tried the pill form and it was too strong for me, but now use an old standby, elixophyllin, a liquid, used for ever as broncho dialator,  CLL seems to cause thick mucous in some patients, I&#8217;m one,  after three pneumonias and almost not able to breathe,  that worked wonders, along with singulair, which I researched and switched to after I tore a shoulder using quinolones (antibiotics) and advair and nasocort, both contain steriods, . seems singulaire has also been used in some cancers.  it&#8217;s main ingred seems to target leukotriens, also a player in cll.<br />
good source for CLL patients&#8230;www.clltopics.org   Chaya is amazing and goes into a lot on alternative, plus trad &#8230; explains so one can understand.  (searchable by substance, disease, trial etc)</p>
<p>cox 2 inhibitors too, but usually perscrip which I can&#8217;t take, GERD&#8230;<br />
looking at Zyflamend for that.  might also help some of the inflamatory pains &#8230; just have to find the time to check the individ ingreds agianst all of my other drugs and add ons. </p>
<p>my bottom line is if something is not toxic, and might help, and reduces symptoms, I&#8217;m on line.   so thanks,  </p>
<p>ps, have had no trad chemo etc,  only IVig infusions once a month due to immunoglobulinemia and repeated pneumonias.  seems to help too.  </p>
<p>wonderful cat you have there.    take care and thanks,   beth</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on IRF4 addiction in multiple myeloma by Andy Muchmore MD</title>
		<link>http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/#comment-4628</link>
		<dc:creator>Andy Muchmore MD</dc:creator>
		<pubDate>Sat, 19 Jul 2008 22:02:47 +0000</pubDate>
		<guid isPermaLink="false">http://margaret.healthblogs.org/?p=846#comment-4628</guid>
		<description>Thought you would be interested - my own personal interest is that I have a plasmacytoma which appears to not have responded completely to radiation.  #1 directly addresses your previous question about inhibitors of IRF4

#1 shows that Vit D3 inhibits IRF4 expression http://www.jleukbio.org/cgi/content/full/77/6/944 - IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1,25-dihydroxyvitamin D3

#2 - shows that Vit D3 down regulates NF-kB J. Biol. Chem, 10.1074/jbc.M308448200
http://www.jbc.org/cgi/content/abstract/M308448200v1

#3 - shows that most patients with myeloma are Vitamin D deficient (there are newer studies as well) - Br J Haematol. 1989 Sep;73(1):57-60. Vitamin D metabolism in myeloma

#4 - shows that Vitamin D3 kills mouse myeloma cells (this is not a very strong paper) Effects of Dexamethasone, All-Trans Retinoic Acid, Vitamin D3 and Interferon- on FO Myeloma Cells - Chemotherapy Vol. 50, No. 4, 2004

There are some Phase I and II studies that seem to suggest that it is possible to get inhibitory levels (i.e. ~ 10nM) of either pulsed Calcitriol (D3) or derivatives Inecalcitol into people with acceptable toxicity</description>
		<content:encoded><![CDATA[<p>Thought you would be interested - my own personal interest is that I have a plasmacytoma which appears to not have responded completely to radiation.  #1 directly addresses your previous question about inhibitors of IRF4</p>
<p>#1 shows that Vit D3 inhibits IRF4 expression <a href="http://www.jleukbio.org/cgi/content/full/77/6/944" rel="nofollow">http://www.jleukbio.org/cgi/content/full/77/6/944</a> - IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1,25-dihydroxyvitamin D3</p>
<p>#2 - shows that Vit D3 down regulates NF-kB J. Biol. Chem, 10.1074/jbc.M308448200<br />
<a href="http://www.jbc.org/cgi/content/abstract/M308448200v1" rel="nofollow">http://www.jbc.org/cgi/content/abstract/M308448200v1</a></p>
<p>#3 - shows that most patients with myeloma are Vitamin D deficient (there are newer studies as well) - Br J Haematol. 1989 Sep;73(1):57-60. Vitamin D metabolism in myeloma</p>
<p>#4 - shows that Vitamin D3 kills mouse myeloma cells (this is not a very strong paper) Effects of Dexamethasone, All-Trans Retinoic Acid, Vitamin D3 and Interferon- on FO Myeloma Cells - Chemotherapy Vol. 50, No. 4, 2004</p>
<p>There are some Phase I and II studies that seem to suggest that it is possible to get inhibitory levels (i.e. ~ 10nM) of either pulsed Calcitriol (D3) or derivatives Inecalcitol into people with acceptable toxicity</p>
]]></content:encoded>
	</item>
</channel>
</rss>
