More on cardamonin and myeloma

After months of being too busy with other stuff, such as…life!, to do much research, I have been going through PubMed again, yaaaay, and this is one of the studies, published in 2015, that really caught my attention: goo.gl/YgMY8OAlpinia_katsumadai_SQ_405_grande

You can actually read the full study online for free, at this link: goo.gl/muftiW

As my blog title suggests, it’s about cardamonin, about which I actually wrote a brief post
in February of 2011 (see http://margaret.healthblogs.org/other-alternative-treatments/cardamonin/). That post was based on a 2010 study, showing, and I quote, that “Cardamonin affects both the STAT3 and NF-kappaB pathways, which, as we know, are crucial for myeloma cell survival and proliferation. It also enhances the anti-MM activity of some conventional drugs used in the treatment of multiple myeloma: vincristine, doxorubicin, dexamethasone, bortezomib and thalidomide..[…] it also has a strong effect against COX2, Bcl-2, Bcl-xL, survivin, VEGF (angiogenesis).” Good stuff!

Cardamonin is extracted from a plant of the ginger family, called Alpinia katsumadai (see photo), which is widely used in Chinese medicine to reduce inflammation, among other things. It also has antibacterial and antiviral effects…

But, as far as we are concerned, the results of the 2015 study confirm those of the 2010 study, that is: cardamonin strongly inhibits myeloma cell activity and proliferation, and, at higher doses, kills the darn cells.

Music to my ears…

Another study that I hadn’t seen, published in 2013, tells us that cardamonin also blocks RANKL, thus suppressing osteoclastogenesis = the process of bone destruction: goo.gl/cFh3QI.

This is also a bit of excellent news for us.

Well, the news would be even more excellent if it were super easy to find cardamonin. Unfortunately, it’s not as simple as going to the health food store and buying some cardamom seeds to add to our food. There are, apparently, seven other Zingiberaceous species, and the cardamom seeds found in stores don’t come from Alpinia katsumadai. For example, in my health food store I found cardamom seeds from Elettaria cardamomum, that is, a different plant altogether. Bummer, eh?

So the search is on! If anyone knows of a reliable, safe source for this stuff, please let me know. But, as always, please be careful and do your research before ingesting anything!

More research needed, but hey, this looks extremely promising…

PLEASE NOTE (note added on March 19): There are different Zingiberaceous species, as I mentioned above. The seeds from Elettaria cardamomum are NOT the same as those from Alpinia katsumadai. The seeds look very similar, but they come from two different plants…Therefore, thanks for sending me the links to different websites that sell Elettaria cardamomum seeds, but it would be pointless and misleading for me to post them. 

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