Margaret's Corner

LIVING WITH SMOLDERING MYELOMA

Most recent comments

• Julie Zimmer on Cancer and diet: Why is nutrition overlooked?
• Paula NZ on Expert Questions US Public Health Agency Advice On Influenza Vaccines.
• Dan on Expert Questions US Public Health Agency Advice On Influenza Vaccines.
• Debra on MGUS for more than 30 years
• Debra on MGUS may increase risk of developing infections…
• John on Relax and Unwind
• bonnie canby on MY DISCOVERY OF CURCUMIN
• Beth on Probiotics and antibodies…
• SMAH on More bullshit…
• SMAH on More bullshit…
• Dieneke Ferguson on Up and down, up and down…
• Kayla on Curcumin: SIDE EFFECTS and WARNINGS
• beatrice nordberg on 14 years!!!
• Hans on 14 years!!!
• Noel on Probiotics and antibodies…
• Paula NZ on Probiotics and antibodies…
• Mary T on Probiotics and antibodies…
• Vijay on A new product: curcumin C3 Reduct
• Bev on Probiotics and antibodies…
• Noel Drew on Myeloma and IGF-1

PAGES

• Contact
  • MARGARET’S CORNER IS ON FACEBOOK!
  • Multiple myeloma support group on Facebook
• General Comments
• GOOD OR BAD FOR MULTIPLE MYELOMA? THIS IS A HELP PAGE WITH LINKS…
  • SMOLDERING FOR 14 YEARS: TAB’s story…
• Living with smoldering myeloma
  • Freelite test interpretation
  • MULTIPLE MYELOMA: WHAT IS IT?
    • C-reactive protein levels
    • CRAB symptoms
      • CRAB symptoms and a blog reader’s story
    • From MGUS to MM: SOX2
      • Does MGUS always precede MM?
        • MGUS for more than 30 years
      • Myeloma triggers
        • Virus connection to myeloma (?)
    • From SMM to MM: IL-1 beta
      • “High-risk” SMM myeloma study: ridikkulous!
      • Case of spontaneous remission in SMM
      • Nicotinamide (vit B), IL-1 beta and PARP cleavage
      • SMM-MM risk of progression
      • SMM: new diagnostic criteria, predictors of outcome, follow-up recommendations
    • Future myeloma treatments (February 2011)
      • JQ1, the Bradner-Harvard team molecule…
    • H. pylori and MGUS
    • Hope…
    • IgE
    • International MM Working Group guidelines for free light chain testing in MM
    • MRIs and gadolinium
    • Myeloma and aplidin
    • Myeloma and beta catenin (& curcumin)
    • Myeloma and CD40
    • Myeloma and celiac
    • Myeloma and DIET
    • Myeloma and ferritin/iron
    • Myeloma and hyaluronic acid
    • Myeloma and IGF-1
    • Myeloma and IL-12
    • Myeloma and IL-17
    • Myeloma and IRF4
    • Myeloma and NIK/TRAF3
    • Myeloma and Polycomb repressor genes
    • Myeloma and pregnancy
    • Myeloma and stress
    • Myeloma and vitamin D
    • Myeloma and vitamin K
    • Myeloma and…cucumbers
    • Myeloma patient and bee venom: a case study
    • Myeloma stem cells
      • General cancer stem cell info
    • Myeloma under age 50
    • Nuclear Factor-kappaB
    • Salinosporamide A, or NPI-0052
  • MY DISCOVERY OF CURCUMIN
    • Bioavailability of curcumin
      • Bioavailability in general
      • CNB-001 = new type of curcumin able to cross the blood brain barrier
      • Curcumin and heat
      • Interview with Prof. Aggarwal (Natural Medicine Journal, December 2009)
      • Piperine
    • Curcumin analogues and nanocurcumin
    • Curcumin and angiogenesis
    • Curcumin and blood clots
    • Curcumin and bone loss
    • Curcumin and bortezomib
      • Bortezomib puts some MM cells to sleep
      • Curcumin, bortezomib and MM
      • Curcumin, chemoresistance, bortezomib and thalidomide
      • Dietary flavonoids and bortezomib
      • EGCG and bortezomib
    • Curcumin and cachexia
    • Curcumin and cigarette smoke
    • Curcumin and cirrhosis
    • Curcumin and H1N1
      • Elderberry and H1N1
    • Curcumin and happiness
    • Curcumin and iron
    • Curcumin and kinases
    • Curcumin and MDM2
    • Curcumin and MyD88
    • Curcumin and NF-kappa B
    • Curcumin and Notch Signaling
    • Curcumin and radiation, pesticides, dioxin etc.
    • Curcumin and the immune system
    • Curcumin reduces breast cancer risk (<HRT)
    • Curcumin, ion channels and cell membranes
    • Curcumin, myeloma and IL-17
    • Curcumin, obesity, diabetes
    • Curcumin: SIDE EFFECTS and WARNINGS
      • Consumer Lab 2011 report on curcumin brands
    • Getting rid of curcumin stains
    • Margaret’s curcumin PROTOCOL
      • BioCurcumax/BCM-95, Jan-Mar 2008
      • Blog readers’ personal stories
        • Smoldering for 12 years
      • Curcumin-chocolate recipe/ricetta curcumina-cioccolato
      • Meriva curcumin
      • My fall 2010 protocol
      • Phase I study of surface-controlled water soluble curcumin (Theracurmin CR-011L)
      • Sherlock’s Page
      • Some 2007 test results
      • Some 2008 test results
      • Some 2009 test results
      • Some 2010 test results
    • MD Anderson curcumin-myeloma clinical trial results
      • Australian MGUS-curcumin clinical trial
      • Curcumin as possible maintenance therapy: Phase II study at MD Anderson, June 2011
      • Curcumin-pancreatic cancer trial results
      • University of Leicester begins bowel cancer-curcumin trial…
  • What is Curcumin?
    • CURCUMIN BRANDS/SOURCES in the U.S. and Europe
      • CURCUMINA IN ITALIA
• MD Anderson curcumin-myeloma clinical trial: preliminary report
• OTHER ANTI-MYELOMA/CANCER SUBSTANCES: RESVERATROL
  • Anthocyanin Pigments
  • Apigenin
  • Arabinoxylan rice bran (MGN-3/Biobran)
  • Ashwagandha/withanolides
  • Avemar
  • Betulinic Acid
  • Black Cumin (Nigella sativa)
  • Boswellic acid
  • Butein
  • Caffeine, VEGF and IL-8
  • Capsaicin
  • Cardamonin
  • Celastrol/Thunder of God
  • Ciclopirox olamine (=nail fungus treatment)
    • Piroctone olamine = antifungal, anti-dandruff AND anti-myeloma?
  • Cyclopamine
  • Dandelion tea
  • DMAPT/parthenolide
    • 2004 Phase I feverfew clinical trial
  • EGCG (from green tea)
    • Bortezomib and EGCG
  • Ellagic Acid
  • Emodin
  • Gambogic Acid
  • Genistein
  • Ginger
  • Glycyrrhizin
  • Gossypin
  • Gossypol analogue
  • Guggulsterone
  • Hesperetin
  • Honokiol
  • Kinetin riboside
  • Moringa oleifera
  • Olive oil/leaves
  • Omega-3
  • Papain (from papaya)
  • Polyherbal Zyflamend
  • Pristimerin
  • Quercetin
  • Reishi/Ganoderma lucidum
  • Saw palmetto/Serenoa repens
  • Scutellaria Baicalensis
  • Sea cucumbers
  • Sesamin (from sesame)
  • SRT501 (resveratrol) trial suspended
  • Thyme oil
  • Ursolic Acid
  • Xanthohumol/hop plant
  • Zalypsis
  • Zerumbone
• Recommended Readings
  • Cancer patients should NOT take N-Acetyl-Cysteine!
  • Diet and Nutrition
    • Acrylamide: bad stuff!
    • Artificial food additives
    • Broccoli
    • Chocolate: Food of the Gods
    • Cooking with Turmeric, and World’s Healthiest Foods
    • Diet and prostate cancer study
    • Fighting RSK2 Activity in MM with…Vindaloo?
    • Healthful food combinations
    • Manuka honey inhibits MRSA etc.
      • Infection fighters: Manuka honey and pomegranates
    • Onions
  • Reversing cancer…NYTimes article
• Related Topics: Antioxidants and Chemotherapy
  • Ayurveda and cancer
  • Breast or melanoma cells?
  • Cancer-resistant people: LIFT
  • CANCER-SUGAR question
  • Chemoresistance, Bcl family, apigenin
  • Circadian rhythm and bioavailabilty
  • Denosumab
  • Genome sequencing of an AML patient
  • Let Spices be Thy Medicine
  • Natural COX-2 and NF-kB Inhibitors
  • p53: tumour suppressor or oncogene?
  • Pets with cancer
  • Prostate Cancer and Multivitamins Study
  • Refined fructose and pancreatic cells study, summer 2010
• Visualizing MM Cells. The Mind and Immunity Function.
  • Laughter and MM :)
    • Amusing (Real!) Patient Reports
    • Bathtub test…
    • Computer Desk Help Humour
    • Dave Barry’s colonoscopy
    • Funny English Signs
    • Funny Page: Are You Afraid of Flying?
    • Funny Physics Story
    • FUNNY/cute videos
    • Jokes for the Immune System
    • Shakespeare for the Immune System
    • Sports funnies
    • Why English teachers retire early
• Ways of cooking broccoli and other recipes
  • Chocolate mousse (no-guilt)
  • Healthful food combinations
• When to Look For Alternative Treatments…
  • Can we overcome the fear of cancer?
  • The cure/control myeloma debate
  • Writing is good for your health!

Complementary/Integrative Treatments

• MD Anderson Complementary/Integrative Therapies

Curcumin in the news

• 2001: “Curry ‘may slow Alzheimer’s',” BBC Health News
• 2003: “More Evidence Curry Ingredient May Fight Cancer,” Reuters Health
• 2005: “Turmeric Shows Promise in Fighting, Preventing Cancer…” Seattle Times
• 2005: Curcumin and melanoma
• 2006: “The healing power of spices,” CBC health news report
• 2007: “Spice Healer…” Scientific American
• 2007: Curcumin and arthritis, USA Today
• 2007: Curcumin…in the supermarket? The Vancouver Sun
• 2007: Turmeric protects against leukaemia, Hindustan Times
• 2008: “Indian Gold,” Men’s Health
• 2008: Curcumin and heart failure
• 2008: Curcumin and pancreatic cancer
• 2008: curcumin and Parkinson’s
• 2008: Natural painkillers
• 2012: Curcumin helps the immune system kill bacteria

Curcumin overview

• 2002: Terri Mitchell’s “Report on Curcumin’s Anti-Cancer Effects”
• 2006: Curcumin: the Indian Solid Gold
• 2007: MD Anderson OncoLog article on curcumin
• Anti-cancer potential of curcumin, presentation by Prof. Aggarwal
• MD Anderson Cancer Research Center, Curcumin FAQ page

Curcumin studies (general)

• 2001: “Therapeutic potential of curcumin in human prostate cancer”
• 2002: Curcumin and colorectal cancer
• 2003: “Molecular mechanisms of curcumin-induced cytotoxicity…” Carcinogenesis
• 2005: “Curcumin Suppresses Growth of Head and Neck Squamous Cell Carcinoma,” Clinical Cancer Research
• 2005: Curcumin and Alzheimer’s disease
• 2007: Curcumin and angiogenesis
• 2007: Curcumin and bladder cancer study
• 2007: Curcumin and ovarian cancer
• 2007: Curcumin, resveratrol, insulin and diabetic neuropathic pain
• 2008: an ancient remedy now in clinical trials
• 2008: curcumin and bladder cancer
• 2008: curcumin and cancer, an “age-old solution”
• 2008: curcumin, VEGF and breast cancer
• 2009: Curcumin and iron
• 2009: Curcumin and lymphoma
• 2009: Curcumin and morphine
• 2009: Curcumin versus neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
• 2009: Xanthorrhizol and curcumin kill breast cancer cells
• 2011: Impact of Curcumin, Raspberry Extract, and Neem Leaf Extract on Rel Protein-Regulated Cell Death/Radiosensitization in Pancreatic Cancer Cells.

Curcumin-MM studies

• 2003: Curcumin, MM cells and IL-6 study, Journal of Immunology
• 2003: Curcumin-MM cells in vitro study, Blood
• 2004: Curcumin, MM cells and chemoresistance, Blood
• 2006: curcumin, myeloma and angiogenesis
• 2007: “Effect of curcumin on expression of survivin, bcl-2 and bax in human multiple myeloma cell line”
• 2007: curcumin potentiates bendamustine in MM cells
• 2008: Curcumin and bortezomib induce apoptosis in MM cells
• 2009: Anti-MM synergy between curcumin and melphalan
• 2009: Curcumin, bortezomib, thalidomide
• 2010: "A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells."
• 2011: "Sensitizing human multiple myeloma cells to the proteasome inhibitor bortezomib by novel curcumin analogs."
• 2011: "Synergistic apoptotic effect of Arabinoxylan rice bran (MGN-3/Biobran) and Curcumin (Turmeric) on human multiple myeloma cell line U266 in vitro."
• 2011: Effect of Curcumin in Combination with Bortezomib on Proliferation and Apoptosis of Human Multiple Myeloma Cell Line H929 and Its Mechanism

Italian curcumin references

• 2001: “Tra i pregi della curcuma, l’attività antitumorale”
• 2003: "Il curry contro il mieloma multiplo"
• 2004: “Curcuma contro la fibrosi cistica,” Le Scienze
• 2004: “Curcuma: dalla cucina alla farmacia,” Kataweb Salute
• 2004: “Dalla curcumina una speranza contro la fibrosi,” Sole 24 Ore
• 2006: “Curcuma antitumorale,” Le Scienze
• 2006: “Mangiare rosso aiuta a combattere il cancro,” Corriere della Sera
• 2006: “Nuclear factor kB e oncogenesi,” del Dr. Vincenzo Cordiano
• 2007: “Curcuma,” Eurosalus
• 2007: “Curcumina, evidenze terapeutiche dell’azione terapeutica”
• 2007: “Fallito tentativo di brevettare la curcumina…” Stampamedica.it
• 2007: “Il curry previene l’Alzheimer”
• 2007: "prevenire il cancro si può"
• 2008: “Le spezie della buona salute”
• 2008: "Dimagrire con il curry?"
• 2008: Curcuma: un possibile aiuto contro il tumore?
• 2009: "A proposito della curcumina"
• 2009: : “Prevenire l’Alzheimer con la curcuma?”
• 2009: Curcumina più efficace contro cancro e Alzheimer
• 2009: “Cancro al seno e Alzeimher: la curcuma è una polvere delle meraviglie.”
• 2009: “Curcuma contro Parkinson e Alzheimer.”
• 2009: “I benefici della curcuma.”
• 2010: Curcumina anti-tumore: nanoparticelle della spezia potenziano le terapie
• 2011: Curcuma e antinfiammatorio: la ricetta giusta per combattere il cancro al colon
• 2011: Tumori. La chemioterapia più forte grazie alla curcumina
• 2012: Curry, un toccasana per l’intestino. Scoperte proprietà anticancro

MM blogs/sites

• Because I said so
• Beth’s Myeloma Blog
• Don’s “Make it a Masterpiece” running blog
• Don’s “Myeloma Hope” Blog
• Facebook multiple myeloma, smoldering myeloma and MGUS support group
• Feresaknit's blog
• International Myeloma Foundation
• John’s Good Blood, Bad Blood
• Join the MMA myeloma patients' listserv!
• Laughing Plasma Cells
• Michael Gearin-Tosh, the .005% survivor
• Mieloma Help (sito italiano)
• Multiple Myeloma Support
• People beating cancer
• PLANET MYELOMA, a collection of MM blogs
• Sunshine’s Blog
• Susie Hemingway – A Power Within
• The Adventures of Cancer Girl

myeloma stem cells

• 2003: Johns Hopkins press release
• 2008: Johns Hopkins press release
• AARC 2008: myeloma stem cell report
• Cancer stem cells, including myeloma
• Excellent presentation on myeloma stem cells
• Myeloma cell study (1977): first mention?

Other cancer blogs etc.

• Barry's CLL blog
• Cancer Compass. It has a good (free) newsletter and some interesting patient forums
• Chronic lymphocytic leukemia (CLL) website
• Green Bananas Cancer Blog
• Jaymun’s Journey

Useful food/spice-related links

• Fanatic Cook
• Informative website on spices, with photos etc.
• World’s Healthiest Foods: good info on a variety of foods/spices/herbs, recipes, free newsletter

Useful links

• "The median isn't the message," by Stephen Jay Gould
• Biology questions and answers
• Genetics home reference
• Health Day
• Lab tests online
• List of companies that test on animals
• Nanocurcumin
• Organic consumers association
• Prof. Kimball’s Biology Pages
• Science Daily

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