Comments on: IRF4 addiction in multiple myeloma http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/ A multiple myeloma blog Sat, 22 Nov 2008 10:12:08 +0000 http://wordpress.org/?v=2.6.3 By: Hallie http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/#comment-4825 Hallie Thu, 14 Aug 2008 16:22:15 +0000 http://margaret.healthblogs.org/?p=846#comment-4825 And Dr. Muchmore, you have answered my prior question about Vitamin D. I will certainly continue to take it! And Dr. Muchmore, you have answered my prior question about Vitamin D. I will certainly continue to take it!

]]> By: Andy Muchmore MD http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/#comment-4628 Andy Muchmore MD Sat, 19 Jul 2008 22:02:47 +0000 http://margaret.healthblogs.org/?p=846#comment-4628 Thought you would be interested - my own personal interest is that I have a plasmacytoma which appears to not have responded completely to radiation. #1 directly addresses your previous question about inhibitors of IRF4 #1 shows that Vit D3 inhibits IRF4 expression http://www.jleukbio.org/cgi/content/full/77/6/944 - IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1,25-dihydroxyvitamin D3 #2 - shows that Vit D3 down regulates NF-kB J. Biol. Chem, 10.1074/jbc.M308448200 http://www.jbc.org/cgi/content/abstract/M308448200v1 #3 - shows that most patients with myeloma are Vitamin D deficient (there are newer studies as well) - Br J Haematol. 1989 Sep;73(1):57-60. Vitamin D metabolism in myeloma #4 - shows that Vitamin D3 kills mouse myeloma cells (this is not a very strong paper) Effects of Dexamethasone, All-Trans Retinoic Acid, Vitamin D3 and Interferon- on FO Myeloma Cells - Chemotherapy Vol. 50, No. 4, 2004 There are some Phase I and II studies that seem to suggest that it is possible to get inhibitory levels (i.e. ~ 10nM) of either pulsed Calcitriol (D3) or derivatives Inecalcitol into people with acceptable toxicity Thought you would be interested - my own personal interest is that I have a plasmacytoma which appears to not have responded completely to radiation. #1 directly addresses your previous question about inhibitors of IRF4

#1 shows that Vit D3 inhibits IRF4 expression http://www.jleukbio.org/cgi/content/full/77/6/944 - IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1,25-dihydroxyvitamin D3

#2 - shows that Vit D3 down regulates NF-kB J. Biol. Chem, 10.1074/jbc.M308448200
http://www.jbc.org/cgi/content/abstract/M308448200v1

#3 - shows that most patients with myeloma are Vitamin D deficient (there are newer studies as well) - Br J Haematol. 1989 Sep;73(1):57-60. Vitamin D metabolism in myeloma

#4 - shows that Vitamin D3 kills mouse myeloma cells (this is not a very strong paper) Effects of Dexamethasone, All-Trans Retinoic Acid, Vitamin D3 and Interferon- on FO Myeloma Cells - Chemotherapy Vol. 50, No. 4, 2004

There are some Phase I and II studies that seem to suggest that it is possible to get inhibitory levels (i.e. ~ 10nM) of either pulsed Calcitriol (D3) or derivatives Inecalcitol into people with acceptable toxicity

]]> By: Alison http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/#comment-4449 Alison Sun, 06 Jul 2008 06:37:34 +0000 http://margaret.healthblogs.org/?p=846#comment-4449 Very interesting Margaret. Thanks for deciphering the research paper for us. The biochemistry of the human body is amazingly complex isn't it - like a giant Rubik's Cube - you change one thing and it affects lots of others. I never did work out how to do the Rubik's Cube. Very interesting Margaret. Thanks for deciphering the research paper for us.

The biochemistry of the human body is amazingly complex isn’t it - like a giant Rubik’s Cube - you change one thing and it affects lots of others.

I never did work out how to do the Rubik’s Cube.

]]> By: carla http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/#comment-4430 carla Sat, 05 Jul 2008 20:45:26 +0000 http://margaret.healthblogs.org/?p=846#comment-4430 About genetic testing for cancer patients: I do not know your experience, but my husband's experience is that it is very difficult to obtain genetic testing in common clinical practice.... I think genetic testing will make clear that chemo drugs benefit only a few subsets of patients who have (or have not) certain genes...but conventional oncologists love their "standard chemo protocols" , and do not care about personalized therapy...... About genetic testing for cancer patients: I do not know
your experience, but my husband’s experience is that it is
very difficult to obtain genetic testing in common clinical
practice….
I think genetic testing will make clear that chemo drugs benefit
only a few subsets of patients who have (or have not)
certain genes…but conventional oncologists love their
“standard chemo protocols” , and do not care about
personalized therapy……

]]> By: Paul http://margaret.healthblogs.org/2008/07/05/irf4-addiction-in-multiple-myeloma/#comment-4421 Paul Sat, 05 Jul 2008 18:07:59 +0000 http://margaret.healthblogs.org/?p=846#comment-4421 Great post Margaret - very interesting. Paul Great post Margaret - very interesting.
Paul

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