So NF-kappa is once again confirmed as a key to the cure of most hematologic cancers (especially together with a p53 upregulator). I first read this on grouppe kurosawa and since then it has been confirmed again and again and again.

Great to hear about 2 potential new substances but in my eyes the easiest way to shut down NF kappa remains green tea / EGCG via the proteasome (were you satisfied with your EGCG tests?) - the in vivo impact of EGCG in humans has been confirmed many times by various studies. I also believe strongly in parthenolide (though it does not affect the proteasome, it has the same effect as EGCG: downregulate NF-kappa and ups p53) but I don’t find anything to make this stuff bioavalable other than with fat.

This report also confirms one more time why blood sugar is a risk as it elevates NF-kappa and explains why it has been implicated quite a few times in the survival statistics of hematologic diseases.

Hope you don’t mind this thought but I got recently concerns about the effectiveness of curcumin in the fight of hematologic cancers. If NF-kappa down and p53 up has been so many times confirmed as the winning formula, curcumin does not compare too well as it reduces NF-kappa less powerfully and its p53 effect is completely questionable. Curcumin is surely otherwise great and will in any case do tremendously more good than harm, but ever since I read on your blog that it’s p53 effect is contradictive, I am not so sure if it’s the best way to follow it on a stand alone basis.